Flaued study on estrogen replacement

A recent study on estrogen replacement which included women without
any consideration to their genetic predisposition , gene mutations or exposure
to evironmental toxins was not very scientific , and inacurate. Nevertheless has
managed to scare many women
Recently I saw a new patient in my office. She was extremely good looking, 70 years
young lady.She owned her good looks to plastic surgery which she underwent five years ago.
Her complaints were related to the brownish , and sometimes pinkish vaginal discharge.
She told me proudly that she never needed estrogen replacement.
My initial thought was that she may suffer from atrophic changes-vaginal and uterine caused
by severe estrogen depravation.
However during transvaginal sonography, my suspicion was that of endometrial cancer.
(the uterine lining was markedly thickened,instead of being pencil thin)
Endometrial biopsy disclosed poorly differentiated adenocarcinoma. In view of her
advanced cancer I referred her to an oncologist.
Should this patient have been included in this study a few years ago, estrogen would be blamed
for causing her cancer.. It is time we should seriously consider the genetic predispositions to
certain cancers, and stop blaming estrogen for everything.
If the cancer occurred when she was taking estrogen the estrogen would modify this cancer
to be well differentiated, which means-less malignant, and her survival rate would be better.